Two sisters, their 8-year-old adopted sister and their mother, try to maintain their relationships and survive their neuroses. One sister is an actress (Emily Mortimer) who is nearly paralyzed by her lack of self-esteem; the other (Catherine Keener) is an unhappily married self-described artist who has never been able to sell any of her work; the 8-year-old (Raven Goodwin) is a confused African-American girl trying to fit in while being constantly reminded that she is different; and, the mother (Brenda Blethyn) is a lonely woman who ends up in intensive care after liposuction surgery -- and with a serious crush on her surgeon. Also with Dermot Mulroney, Michael Nouri, James LeGros and Jake Gyllenhall. [1:31]

SEX/NUDITY 6 - A woman stands fully nude (we see her nude from the front and the back) in front of a man and he analyzes her body. A young man and woman kiss passionately in the back seat of a car. A man and woman read a script for a scene where the two are supposed to be lusting for each other, and they kiss passionately and lie back on a couch with her leg wrapped around his hip. A man and woman kiss and he caresses her clothed breast. A man and woman kiss a couple of times, and a young man and older woman kiss a couple of times. A woman wears a dress that has a sheer bodice and exposes her bare breasts. A man and woman lie in bed together and we see her bare shoulders and his bare chest. A young man flirts with an older woman. A woman is shown in her bra and panties at a doctor's appointment for liposuction mapping. A woman wears a bikini. A woman talks to her daughter about having sex with two partners at the same time. A woman talks about a man being sexy and a woman talks about whether or not she is sexy. A man asks a woman what she thinks is sexy and what kind of sex she has with her boyfriend. A woman asks a man if he's still attracted to her.

VIOLENCE/GORE 3 - An African-American girl says, "I want to tear my skin off...to be like you." A woman falls on the floor when she gets out of bed in a hospital, and cannot get back up. We see a dog with stitches on its stomach, and another one with a cone around its neck. A girl plays dead in a swimming pool and her companion panics and yells at her (the girl does this a couple of times). We hear a dog snarl and snap at a woman and see her later with a bloody, stitched wound on her lip. Two girls yell at each other. A woman is taken away in handcuffs and charged with statutory rape. A man talks about his wife having had a bladder infection and a yeast infection. We see photographs of a newborn baby covered with goo.

LANGUAGE 6 - 16 F-words, 9 sexual references, 1 obscene sexual hand gesture, 7 scatological terms, 11 anatomical terms, 11 mild obscenities, 6 religious exclamations, 1 derogatory term for homosexuals, and some name-calling.

SUBSTANCE USE - People are shown drinking alcohol and smoking cigarettes. One scene shows an older woman taking an underage young man into a bar and buying him alcohol. A girl talks about her mother being on crack.

DISCUSSION TOPICS - Disappointment, jealousy, neuroses, insecurity, rejection, manipulative behavior, infidelity, indifference, self-involvement, drug addiction, drug addicted mothers, sympathy, narcissism, statutory rape.

MESSAGE - Our family members are often the only people who can understand and forgive our foibles.